RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-15a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
PCR etc.
Target
TGFBR1;CTGF;P53
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart
Year
2017
Function
"Therapeutic restoration of miR-15a and -15b in HL-1 cardiomyocytes reduced the activation of pro-fibrotic TGF-betaRi and CTGF, and the pro-senescence p53 protein expression, confirming a causal regulation of these fibrotic and senescence mediators by miR-15a/b."